Rheumatoid Arthritis is a chronic inflammatory disease affecting more women than men. It is a symmetrical progressive condition which usually affects the small joints of the hands and feet. Onset can be at any age. Fatigue may be a significant symptom. In addition to joints, organs can be involved. Treatment is designed initially at suppressing inflammation. Biologic agents (i.e. Enbrel, Humira, Remicade) have made a significant difference in improving the lives of patients with this disease.